郑楠简介
郑楠，女，1993年生，博士，讲师，2025年毕业于江南大学发酵工程专业。多年以来，一直从事微生物分子酶学与催化工程的理论及应用等方面的研究。在国内外学术刊物上发表学术论文20余篇，授权发明专利5项。
研究方向：AI辅助的酶工程策略开发及在食品加工中的应用
代表性成果：
1. Nan Zheng, Yongchao Cai, Zehua Zhang, Huimin Zhou, Yu Deng, Shuang Du, Mai Tu, Wei Fang, Xiaole Xia*. Tailoring industrial enzymes for thermostability and activity evolution by the machine learning-based iCASE strategy. Nature Communications, 2025, 16, 604.
2. Zidan Liu, Weihao Long, Keying Chen, Linyu Luo, Qiong Li, Tolbert Osire, Nan Zheng*, Mengfei Long*. Function and Engineering of a Food Enzyme Under Coupled High-Temperature–Pressure Conditions: Insights from Molecular Dynamics Simulation and Experimental Validation. Foods, 2025, 14, 2485.
3. Nan Zheng#, Mengfei Long#, Zehua Zhang, Shuang Du, Xinlei Huang, Tolbert Osire, Xiaole Xia*. Behavior of enzymes under high pressure in food processing: mechanisms, applications, and developments. Critical Reviews in Food Science and Nutrition, 2024, 64, 9829-9843.
4. Nan Zheng#, Mengfei Long#, Zehua Zhang, Tolbert Osire, Qijia Zan, Huimin Zhou, Shuang Du, Xiaole Xia*. Functional, structural properties and interaction mechanism of soy protein isolate nanoparticles modified by high-performance protein-glutaminase. Food Hydrocolloids, 2023, 139, 108594.
5. Nan Zheng#, Ling Gao#, Mengfei Long, Zehua Zhang, Cailin Zhu, Xiang Lv, Qingtong Zhou, Xiaole Xia*. Isothermal Compressibility Perturbation as a Protein Design Principle for T1 Lipase Stability-Activity Trade-Off Counteracting. Journal of Agricultural and Food Chemistry, 2023, 71, 6681-6690.
6. Nan Zheng#, Mengfei Long#, Zehua Zhang, Qijia Zan, Tolbert Osire, Huimin Zhou, Xiaole Xia*. Protein-Glutaminase Engineering Based on Isothermal Compressibility Perturbation for Enhanced Modification of Soy Protein Isolate. Journal of Agricultural and Food Chemistry, 2022, 70, 13969-13978.
7. Nan Zheng, Sen Jiang, Yahui He, Yefu Chen*, Cuiying Zhang, Xuewu Guo, Lijuan Ma, Dongguang Xiao. Production of low-alcohol Huangjiu with improved acidity and reduced levels of higher alcohols by fermentation with scarless ALD6 overexpression yeast. Food Chemistry, 2020, 321, 126691.
主持、参与项目：
1. 江苏省研究生科研创新工程基金项目，基于动态耦合βT微扰工程策略提高蛋白质谷氨酰胺酶鲁棒性(KYCX22_2363)，2022.03-2023.09，主持
2. 国家重点研发计划项目，功能性维生素绿色生物制造关键技术研究（2023YFF1103700），2023.12-2027.12，参与
3. 国家重点研发计划项目，高性能生物纺织酶基因的挖掘与分子改造（2021YFC2104001），2021.12-2025.05，参与
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